However, the top Shenzhen scorer was substituted with a suspected groin strain in the 43rd minute.
The Curitiba-based side top the Group C standings with six points from three matches, ahead of Chile's Colo-Colo on goal difference. Jorge Wilstermann are third with three points.
Elsewhere on Tuesday, Ecuador's LDU Quito secured a 1-0 win away to Peru's Binacional, courtesy of a first-half goal from Matias Zunino.
Despite Thursday's result, Flamengo are second in their Libertadores group with six points from three matches but with a negative goal difference. The Rubronegro remained in Ecuador after the clash in Quito to prepare for Tuesday's fixture against Barcelona SC in the Pacific port city of Guayaquil.
The region's premier club tournament, the Copa Libertadores, was due to resume on Tuesday, having been suspended in mid-March.
Leo Messi scored twice, and set up Philippe Coutinho, to show that he is fully committed on the pitch after a summer in which it looked as if he had a foot outside the door of the Camp Nou, while Barca produced a mobile performance in a side that contained Messi, Antoine Griezmann, Coutinho and newcomer Francisco Trincao.
Gilvan Correa pulled a late goal back for the hosts with a stoppage-time header following an Everton Felipe corner.
Esteghlal parted company with Farhad Majidi at the end of Iran's super league season and reportedly has not reached an agreement with Italian coach Andrea Stramaccioni.
The second half saw Sharjah take the first lead after Moroccan defender Medhi Benatia received a red card for an elbow on Sharjah playmaker Igor Coronado, who beat the goalkeeper with a curled effort, but the ball bounced off the upright and fell to midfielder Majed Surour whose diving header help Sharjah establish the lead for the first time in the tie.
Flamengo had never before lost a Copa Libertadores match by a five-goal margin. Previously, their worst showing in South America's premier club competition was a 5-1 capitulation to Gremio in 1984. Thursday's result was also the heaviest defeat by defending Copa Libertadores champions.
Events in indoor and outdoor arena will be separate.