The arrival of the national quartet of Li, Yang Liwei, Huang Sijing and Li Yuan meant Inner Mongolia, playing in the WCBA for the second year, emerged as a rising powerhouse.
Khachanov won the pair's previous encounter in Paris - at 2018 Paris Masters, when the Russian claimed a straight-set win in the final to clinch the biggest title of his career until now.
Li Xiu led Wuhan with 14 points, but no other player scored in double figures. Wuhan was held to 3 of 26 shots beyond the arc.
The club said that four outfielders and three infielders have been infected with the virus, as well as four non-playing staff, bringing the total number of recent infections at the club to 13 after it was revealed on Sunday that right-hander Daiki Iwashita and a staff member had tested positive.
New arrival Pedro Rodriguez scored the winner after the break as the Spaniard unleashed a missile into the net with both power and precision.
Rennes kept its lead in the standings over Lille on goal difference, although its four-match winning streak ended with a 2-2 draw against second-from-bottom side Stade Reims.
Head coach Li Tie expressed gratitude for the CSL clubs and the players' participation. "They have endured intensive games and training for 70 days, which was very tough, but they made it through. I myself once took part in a lot of training camps with the national team and I understand they might want to spend more time with their family during the break," he said.
Without Li Yueru protecting the rim, Hebei trimmed the deficit to six points midway through the second quarter, but it was the closest they would come. Li responded by scoring eight points from the bench. Inner Mongolia held their nerve to build a 46-31 halftime lead.
Al Nassr broke the deadlock with a penalty in the 35th minute before Abdi Mehdi Qara leveled for Persepolis just six minutes later.
Next up for Halep is another 19-year-old youngster, Iga Swiatek of Poland, whom Halep defeated in the round of 16 here last year.
Burel wasted three set points when she took a 5-3 lead in the first set and stormed to 40-0 in the ninth game. But Zhang battled back to save all three, and held the serve before breaking Burel's in the tenth to level the score at 5-5.